![]() ![]() Both have the potential for drug interactions. And make sure you mention any other prescription medications or supplements you’ve given your pet to your veterinarian so he or she can check for drug interactions. You should be cautious when giving any medication to your pet. Sentinel contains Lufenuron, which prevents flea egg development and ends the flea life cycle, but doesn’t kill adult fleas Trifexis contains Spinosad, which kills fleas (it has been proven to kill 100% of all biting fleas within four hours). Sentinel can be given to dogs as small as 2 pounds Trifexis can be given to dogs as small as 5 pounds. Sentinel can be given to puppies at beginning at 4 weeks Trifexis can be given to puppies beginning at 8 weeks. One dose of Sentinel costs about $5 less than one dose of Trifexis.
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